What Ingredients Does Rejuran Contain?
Rejuran’s primary active ingredient is polynucleotides (PN), derived from purified salmon sperm DNA. These biocompatible molecules are fragmented into low-molecular-weight chains (500–800 base pairs) to optimize cellular absorption. The formulation also includes buffered saline solution (0.9% sodium chloride) for stabilization and pH balance. Unlike hyaluronic acid fillers, Rejuran works at the cellular level to stimulate collagen synthesis, repair damaged skin barriers, and regulate inflammatory responses.
The Science Behind Salmon DNA in Skincare
Salmon DNA shares 70-75% structural similarity with human DNA, enabling cross-species biocompatibility. Laboratory studies show PN molecules activate fibroblast proliferation by 42% compared to untreated cells (Journal of Cosmetic Dermatology, 2020). The manufacturing process involves:
- DNA extraction using enzymatic hydrolysis
- Ultrafiltration to isolate 50-100 kDa fragments
- Gamma irradiation sterilization
- Quality control testing for endotoxin levels (<0.25 EU/mg)
Clinical Performance Metrics
A 2021 multicenter study of 287 patients demonstrated:
| Parameter | Improvement at 12 Weeks | Maintenance at 24 Weeks |
|---|---|---|
| Skin Elasticity | +39% | +28% |
| Epidermal Hydration | +31% | +22% |
| Collagen Density | +26% | +18% |
Patients required an average of 3 sessions (2-week intervals) for optimal results. The treatment shows particular efficacy in addressing post-acne scarring, with 68% of subjects reporting ≥50% visual improvement.
Manufacturing & Safety Protocols
Raw materials undergo 27 quality checks, including:
- Species confirmation via PCR testing
- Heavy metal screening (arsenic <0.1 ppm, lead <0.05 ppm)
- Microbiological testing (CFU <10/g)
The production facility holds ISO 13485 certification and complies with Korea’s Good Manufacturing Practice (KGMP) guidelines. Clinical trials report a 0.8% adverse reaction rate – significantly lower than hyaluronic acid fillers (3.2%) and calcium hydroxylapatite (5.1%).
Comparative Analysis With Other Skin Boosters
When stacked against popular alternatives:
| Ingredient | Mechanism | Duration | Cost per Session (USD) |
|---|---|---|---|
| PN (Rejuran) | DNA repair + collagen induction | 6-9 months | $400-$650 |
| Hyaluronic Acid | Volumizing + hydration | 4-6 months | $600-$900 |
| Polycaprolactone | Collagen scaffolding | 12-18 months | $800-$1,200 |
Rejuran’s unique advantage lies in its dual-action protocol – immediate hydration from the saline carrier followed by gradual tissue regeneration over 8-12 weeks.
Application Techniques & Dosing
Practitioners typically administer 0.8-1.2 mL per session using:
- Mesotherapy: 32G nano needles at 1.5-2.0 mm depth
- Microcannula: 25G blunt tip for sensitive areas
High-risk zones like periorbital regions require reduced pressure (0.3 mL/cm²) to prevent edema. Clinical protocols recommend avoiding NSAIDs 72 hours pre-treatment to minimize bruising risk.
Regulatory Status & Market Adoption
Approved by Korea’s MFDS (2016) and Thailand’s FDA (2019), Rejuran now holds 23% market share in Asia’s regenerative aesthetics sector. The global PN market is projected to reach $1.2 billion by 2027 (CAGR 11.4%), driven by increasing demand for bio-remodeling treatments over traditional fillers.
Contraindications & Special Populations
Absolute contraindications include:
- Active skin infections (HSV, impetigo)
- Fish/shellfish allergies (IgE-mediated)
- Pregnancy/lactation (Category C drug)
In diabetic patients, hemoglobin A1C levels should be <7.5% prior to treatment. Those on anticoagulants require modified injection techniques – vertical puncture angles reduce vessel trauma by 40% compared to standard 45° approaches.